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Austin-based business making strides toward Alzheimer’s disease treatment

Published Wed, 05 Mar 2025 04:11:19 GMT

AUSTIN (KXAN) –  An Austin-based pharmaceutical company is making promising strides toward developing a new treatment for Alzheimer’s disease. Cassava Sciences has been researching neurodegenerative conditions for over a decade. In a recent trial, one of their medications – simufilam – showed slowed cognitive decline by 38% in patients with mild-to-moderate Alzheimer’s disease who had the medication versus patients taking a placebo. “In my opinion, that's a remarkable finding,” CEO and president of Cassava Sciences, Remi Barbier, said. “Alzheimer's makes cancer look like child's play. What we're talking about is a brain with over three billion cells, all of which are interconnected, starting to act up and decay. How do you treat 3 billion anything? It's very, very difficult,” Barbier added. More often in clinical trials, one group will receive the experimental medication while another group will receive a placebo – something like a sugar pill or saline injection ...

Teen who shot 12-year-old brother in St. Paul released from custody pending further investigation

Published Wed, 05 Mar 2025 04:11:19 GMT

A 14-year-old boy who fatally shot his 12-year-old brother last weekend at a home on St. Paul’s North End was released from custody Tuesday without charges after prosecutors say there was not “sufficient evidence to proceed with a charging determination.”The Ramsey County attorney’s office said in a Tuesday afternoon statement it has returned the case to St. Paul police “following a careful review of the evidence presented by law enforcement.”“The RCAO will make a charging determination at a future date should additional investigative information become available,” the statement said. “Based upon this decision by the RCAO, the youth will be released from custody.”Police said Tuesday the investigation is still active and remains open.Denisha Hill, the mother of both boys, told the Pioneer Press on Monday that Saturday’s shooting was “a terrible accident.” Although she said she doesn’t know exactly what happened, she thinks her 14-year-old was playing with the gun and didn’t kno...

Fringe review: ‘Wells is Third on the Waitlist’ is clever, nerdy and delightfully self-referential

Published Wed, 05 Mar 2025 04:11:19 GMT

Worth consideringComedian Wells Farnham, who for years has been waitlisted, finally won the Fringe lottery and got his own show. He never thought this day would come — which, now, is the problem. During this clever and self-referential comedy set, a world-weary and delightfully public-policy-obsessed Farnham becomes increasingly unhinged as he tries to figure out what his Fringe show should be about. “Wells is Third on the Waitlist” truly did come together somewhat last-minute, and that’s apparent. But Farnham’s jokes are smart, his writing is mostly tight and sharp, and his outraged delivery is just fun to watch. The show is a sleeper hit.Presented by Wells Farnham at Augsburg Studio; 10 p.m. Aug. 8, 8:30 p.m. Aug. 11, 10 p.m. Aug. 12Still unsure of what to see? Check out all our Fringe reviews here.The Minnesota Fringe Festival turns 30 this year, presenting 101 hourlong stage acts from Aug. 3-13 at theaters throughout Minneapolis. Pioneer Press reporters will post the...

Lebanese restaurant sets opening date in Watervliet after move

Published Wed, 05 Mar 2025 04:11:19 GMT

WATERVLIET, N.Y. (NEWS10) -- Teta Marie’s Lebanese Restaurant is ready to open at its new home in Watervliet. Owner Brenda Hage announced the restaurant is opening on August 15 at 2 p.m. after its ribbon cutting. Get the latest news, weather, sports and entertainment delivered right to your inbox! Teta Marie's moved from Ontario Street in Cohoes to the old Papa’s building at 1297 Broadway in Watervliet. Hage said the restaurant outgrew its spot in Cohoes after its first year and a half.Hage opened Teta Marie's in September 2020. She said she initially looked at the old Papa's building as a spot to open the restaurant but ultimately went with the Cohoes location. Filli’s opens Express Store in New Lebanon "It felt like it was meant to be," said Hage. She and her husband spent the last four and a half months working on the new space.The restaurant serves Lebanese food such as falafel, stuffed grape leaves, kabobs, shawarma, salads, and more. In the new space, Teta Marie's will hav...

Fatal crash under investigation in Highland

Published Wed, 05 Mar 2025 04:11:19 GMT

HIGHLAND, N.Y. (NEWS10) -- Investigations into a fatal two-car crash on Sunday morning are ongoing. According to the Town of Lloyd Police, the accident happened on Route 9W near Chapel Hill Road. Get the latest news, weather, sports and entertainment delivered right to your inbox! Police say a 21-year-old Poughkeepsie man was driving southbound in a 2008 Ford Explorer. The Explorer crossed into the northbound lane and struck a 2016 Chevy Cruse traveling north. The 50-year-old driver of the Chevy Cruse sustained internal injuries and was transported to Vassar Hospital by the New Paltz Rescue Squad. A 52-year-old passenger in the Chevy Cruse was transported to the Mid-Hudson Regional Hospital by the Mobil Life Ambulance. The passenger succumbed to her injuries.The driver of the Ford Explorer was uninjured. Names are being withheld pending family notification.

52 days on the road: A migrant family’s desperate journey to Chicago

Published Wed, 05 Mar 2025 04:11:19 GMT

Nell Salzman | Chicago TribuneEsperanza Beatriz Mendez didn’t get to say goodbye to her mother before leaving her home in Venezuela with her three children.Her mother, whom she called the most important person in her life, was so strongly opposed to her making the dangerous trek to the U.S. that she wouldn’t say goodbye. Esperanza sobbed outside her mother’s house, but she knew she needed to leave, she said.“I have plans: The first is to work and buy a house and bring my mom,” she said in Spanish. “I hope she’s doing OK, that she hasn’t fallen into depression, and that she’ll wait for me.”Esperanza and her children fled Venezuela to escape an economic collapse that had shut down her kids’ schools and her city’s grocery stores. Their goal now: to make it to Chicago and meet a relative.The group of five — Esperanza, her three kids and her son’s pregnant girlfriend, plus the family dog — trekked over 3,000 miles for more than seven weeks and survived Panama’s Darién Gap, a harrowing ju...

How to look at the pros and cons of independent living as we age

Published Wed, 05 Mar 2025 04:11:19 GMT

By Helen Dennis | Southern California News GroupQ. One of my concerns about getting older is losing my independence, particularly since I am a very independent older woman. The thought of having to rely on someone else for my well-being is not only uncomfortable but scary. How does one come to grips with this?  A.R.Most older adults have spent their entire lives living independently. They worked, earned money, supported themselves, raised families and made their own decisions for decades. Yet aging can bring about changes that lead to becoming more dependent. These include financial difficulties, inability to care for oneself both physically and mentally or having to relocate because of limitations.The topic is on many people’s minds as indicated by surveys as well as conversations with friends. One survey ranked fear of becoming dependent in later life as the No. 1 concern followed by safe issues and memory loss. Another survey ranked it No. 4 after loneliness, declining health and...

A trans girl testified against a Texas bill at 10. After death threats she moved to Connecticut to be safe.

Published Wed, 05 Mar 2025 04:11:19 GMT

There were no questions from the Texas Senate Committee on State Affairs when Kai Shappley, then 10, testified against a bill that would charge parents who affirm their transgender children’s gender identity with child abuse.“Seriously, none of y’all want to know more about me?” she asked as she rose from her chair.The bill failed, but Gov. Greg Abbott signed an executive order accomplishing the same goal.Plenty of people have learned about Kai, now 12, whose story as a trans girl went viral, including a story in Vogue magazine.Larry St. PierreKai Shappley, left, with her mother, Kimberly, and brother, KalebA year ago, Kai, her mother, Kimberly, and 10-year-old brother Kaleb, two of seven siblings, moved to Connecticut as “political refugees” to escape the death threats and anti-transgender attitudes in Texas, where they were subjected to abuse and the loss of family and friends.Now, Kai has “an army of crabs,” discovering the horseshoe crabs and hermit crabs in Long Island Sound ne...

Woman with car trouble hit, killed by semi-truck on 101 Freeway in L.A.

Published Wed, 05 Mar 2025 04:11:19 GMT

A woman who got out of her vehicle was struck and killed on the 101 Freeway, prompting lane closures through the Echo Park area of Los Angeles Tuesday morning.California Highway Patrol units responded to the incident around 3:45 a.m. on the southbound side of the freeway near Alvarado Street. The victim apparently had some sort of car trouble and stopped on the freeway to check the problem, CHP Sgt. Jensen said.First responders investigate a fatal crash on the 101 Freeway in the Echo Park area on Aug. 8, 2023. (KeyNews.TV)For unknown reasons, she walked into traffic lanes and was struck, Jensen said. She was pronounced dead at the scene. Her identity was not immediately released.There were no indications of foul play regarding the incident, which "seems like an accident," Jensen said. Third suspect arrested in connection with murder of teen in Irvine All lanes on the southbound side of the 101 Freeway were shut down at Alvarado for several hours for the investigation.

Optimize Your Trades: Top Crypto Apps of the Year

Published Wed, 05 Mar 2025 04:11:19 GMT

As cryptocurrencies transition from an intriguing novelty to a booming mainstream industry, the demand for reliable, user-friendly, and richly-equipped trading platforms soars. Whether you’re an established investor or a newcomer charting the waters of digital currency, this review will introduce you to this year’s five preeminent crypto apps to elevate your trading game.Binance: The Titan of TradeFirst, we spotlight Binance, a platform whose reputation reverberates within the digital asset marketplace. This formidable player claims the highest global trading volume in the cryptocurrency sphere. From novices to experienced traders, Binance greets everyone with an extensive list of tradeable digital currencies, not just limited to Bitcoin and Ethereum.Binance garners attention for its sophisticated trading capabilities, including futures and margin trading, a boon for the daring. A blend of superior security measures and a smooth user interface makes Binance desirable for...